PhD in Molecular, Experimental and Computational Medicine (MECM)

Places 8
Duration 3 Years
Language English

Applications for the academic year 2026/2027 are open


The Programme


1. MECM Standard


2. MECM Clinical


3. MECM Data Science

Michela Matteoli

Full Professor Pharmacology View Profile

Places available

Language

Duration

Beginning of teaching activities

Application deadline

Contacts


Programme Objectives


Career Opportunities


Didactic Activities


Admission Requirements

MECM-Clinical Curriculum


Fees and Scholarships


How to Apply


Admission process


Academic Board

NamePrincipal AffiliationDepartmentE-mail
Absinta Martina麻w豆传媒Biomedical Sciencesmartina.absinta@hunimed.eu
Asselta Rosanna麻w豆传媒Biomedical Sciencesrosanna.asselta@hunimed.eu
Bonecchi Raffaella麻w豆传媒Biomedical Sciencesraffaella.bonecchi@hunimed.eu
Costanzo Antonio麻w豆传媒Biomedical Sciencesantonio.costanzo@hunimed.eu
Di Mitri Diletta麻w豆传媒Biomedical Sciencesdiletta.di_mitri@hunimed.eu
Di Tommaso Luca麻w豆传媒Biomedical Sciencesluca.di_tommaso@hunimed.eu
Garlanda Cecilia麻w豆传媒Biomedical Sciencescecilia.garlanda@hunimed.eu
Greco Carolina麻w豆传媒Biomedical Sciencescarolina.greco@hunimed.eu
Inforzato Antonio麻w豆传媒Biomedical Sciencesantonio.inforzato@hunimed.eu
Kallikourdis Marinos麻w豆传媒Biomedical Sciencesmarinos.kallikourdis@hunimed.eu
Kon Elizaveta麻w豆传媒Biomedical Scienceselizaveta.kon@humanitas.it
Italian National Council for ResearchPharmacology and Brain Pathology Labmarianna.leonzino@humanitasresearch.it
Lodato Simona麻w豆传媒Biomedical Sciencessimona.lodato@hunimed.eu
IRCCS Humanitas Research HospitalBiomedical Sciencesenrico.lugli@humanitasresearch.it
Matteoli Michela麻w豆传媒Biomedical Sciencesmichela.matteoli@hunimed.eu
Italian National Council for ResearchPharmacology and Brain Pathology Labelisabetta.menna@humanitasresearch.it
Ng Kiu Yan Charlotte麻w豆传媒Biomedical Scienceskiu.ng@hunimed.eu
Politi Letterio Salvatore麻w豆传媒Biomedical Sciencesletterio.politi@hunimed.eu
Pozzi Davide麻w豆传媒Biomedical Sciencesdavide.pozzi@hunimed.eu
Rescigno Maria麻w豆传媒Biomedical Sciencesmaria.rescigno@hunimed.eu
Simonelli Matteo麻w豆传媒Biomedical Sciencesmatteo.simonelli@hunimed.eu
Sold脿 Giulia Maria Emilia Antonietta麻w豆传媒Biomedical Sciencesgiulia.solda@hunimed.eu
Spinelli Antonino麻w豆传媒Biomedical Sciencesantonino.spinelli@hunimed.eu
Stefanini Giulio Giuseppe麻w豆传媒Biomedical Sciencesgiulio.stefanini@hunimed.eu
Terracciano Luigi Maria麻w豆传媒Biomedical Sciencesluigi.terracciano@hunimed.eu
Vetrano Stefania麻w豆传媒Biomedical Sciencesstefania.vetrano@hunimed.eu

Research Topics a.y. 2026/2027

TOPICCURRICULUMRESEARCH SUPERVISOR LABORATORY NAMEPROJECT TITLE
MECM 1StandardMassimiliano MazzoneLab of Macrophage DynamicsTargeting macrophage recruitment and metabolic reprogramming to counteract liver metastases (MARVEL)
MECM 2StandardGiulia MarelliTumour Microenvironment UnitDeciphering the gut鈥損rostate immune axis to improve response to anti-PD-1 immunotherapy
MECM3ClinicalGiulio StefaniniCardiovascular Department, IRCCS Humanitas Research HospitalOptimizing treatment strategies: reduced stent strategy versus conventional percutaneous coronary revascularization in patients with acute myocardial infarction.
MECM5StandardSergio Marchini / Raffaella BonecchiUnit of Translational Genomics / Laboratory of Cancer PharmacologyMultimodal genomic and microenvironmental profiling to predict relapse risk in early-stage epithelial ovarian cancer
MECM6StandardMaurizio D鈥橧ncalci / Lara ParacchiniLaboratory of Cancer PharmacologyDiagnosis of tubal malignant ovarian cancer precursor lesion through the analysis of DNA from Pap test smear
MECM7ClinicalMaurizio D鈥橧ncalci / Monica Lupi / Lavinia MorosiLaboratory of Cancer PharmacologyMechanisms of resistance to mirvetuximab soravtansine in patients with high-grade serous ovarian cancer and platinum-resistant relapse
MECM8ClinicalVincenzo Ronca /Ana LleoHepatobiliary ImmunopathologyInnovative Strategies for Modulating Immune Tolerance in Autoimmune Hepatitis: Antigen-Specific Tregs and Nanoparticle-Enhanced Liver Delivery
MECM9StandardGabriele TodiscoGenomics of Hematological Malignances LabMutation Driven Inflammation as a Driver of Cancer Evolution: A Proteomic Discovery Platform in Myeloid Neoplasms and Clonal Hematopoiesis
MECM12StandardLeonardo Elia / Gianluigi CondorelliVascular EpigeneticsSmooth muscle cell phenotypes at the single-cell level: specific role
during atherosclerosis development in humans
MECM14StandardAntonio InforzatoLaboratory of Cellular and Humoral Innate ImmunityProcesses and mechanisms of innate immunity at the host-pathogen interface in bacterial
osteomyelitis
MECM15StandardSebastiano BariselliPharmacology and Brain Pathology Lab – Team of Neurocircuits of Care and VulnerabilityDissecting alcohol-induced maternal neurobehavioral reprogramming
MECM16StandardCarolina Magdalen GrecoCircadian Metabolism LabIdentification of heart secreted factors underlying systemic metabolic changes in heart failure
MECM17StandardMatteo Fossati / Davide PozziCell Biology of the SynapseEnvironmental Exposure and Mental Health: The Entanglement of Particulate Matter and Diet in the severity of schizophrenia spectrum disorders
MECM18Data ScienceAntonietta Franco / Gianluigi CondorelliImmunology in Cardiovascular Pathologies LabTreating cardiomyopathy in MERRF syndrome through mitochondrial capture therapy
MECM19StandardRosanna Asselta / Maria Elisa MancusoLab of Medical Genetics & RNA BiologyIntegrated multi-omics and functional characterization of inherited bleeding disorders: towards personalized hemostatic medicine
MECM20StandardMartina AbsintaExperimental NeuropathologyGlial-enriched stem-cell 3D model of smoldering inflammation in multiple sclerosis: towards a drug screening cellular platform
MECM21StandardMichela MatteoliLaboratory of Pharmacology and Brain PathologyAddressing metabolic and functional defects in neurons and oligodendrocytes in Nasu-Hakola Disease
MECM23StandardCarolina Magdalen GrecoCircadian Metabolism LabCircadian Regulation of Immune Responses in Cardiac Fibrosis and Heart Failure
MECM24StandardLeonardo Elia / Gianluigi CondorelliVascular EpigeneticsInfluence of DOT1L on smooth muscle cell phenotypes at the single-cell level: specific role
during atherosclerosis development in humans
MECM26StandardPaolo BossiTranslational Genomic UnitTranslational correlates of 3 clinical trials aimed to predict and intercept the malignant transformation of oral potentially malignant disorders and to treat oral cavity cancers
MECM27Data ScienceCostantino Pitzalis / Maria Rita FumagalliRheumatology – Multiscale and Nanostructural Imaging UnitIntegrative approaches for the digital spatial profiling of immune and inflammatory microenvironment in multi-drug resistant rheumatoid arthritis.
MECM28StandardMaria RescignoMicrobiota & mucosal immunologyInvestigating the role of tumor-resident bacteria in dictating organ-specific cancer cell dissemination during metastatic events
MECM29StandardMichela MatteoliLaboratory of Pharmacology and Brain PathologyMODELING SEX-SPECIFIC LYMPHOCYTE鈥揋LIA INTERACTIONS IN MS USING A HUMANIZED BBB PLATFORM
MECM33StandardSara Lovisa / Gennaro NappoPlasticity, Fibrosis and Cancer LabIdentification of tissue signatures to predict and intercept the malignant evolution of intraductal papillary mucinous neoplasms (IPMNs)
MECM34StandardSara Lovisa / Matteo LigorioPlasticity, Fibrosis and Cancer Lab / Ligorio Lab, UT Southwestern, Dallas (USA)Unraveling determinants of pancreatic cancer progression

Research Topics a.y. 2025/2026

TOPICCURRICULUMRESEARCH SUPERVISOR LABORATORY NAMEPROJECT TITLE
MECM 1StandardEduardo BonavitaCellular and Molecular OncoimmunologyInvestigating cholesterol metabolism in cancer and its impact on the tumor microenvironment and dendritic cell function
MECM3StandardCecilia GarlandaLaboratory of Experimental ImmunopathologyRole of IL-1R2 in myeloid cells in cancer
MECM4StandardMarianna LeonzinoLab 35 鈥 Building ERole of membrane contact sites in movement disorders
MECM5StandardMichela MatteoliPharmacology and brain pathologyInvestigating the gender-based molecular mechanisms underlying synaptic refinement in neurodevelopmental and neurodegenerative disorders.
MECM6StandardJaillon SebastienInnate immunity in inflammation and cancerUnveiling the dynamics of neutrophil recruitment and heterogeneity in cancer
MECM7StandardJaillon SebastienInnate immunity in inflammation and cancerTargeting immunosuppressive neutrophil subsets in cancer
MECM8Data ScienceDiletta Di MitriTumor Microenvironment Unit, 麻w豆传媒Bioinformatic approaches to analyze the tumor microenvironment and identify mechanisms of therapeutic resistance in cancer
MECM9StandardDiletta Di MitriTumor Microenvironment Unit, 麻w豆传媒Identification of prognostic and predictive biomarkers of therapeutic response in cancer
MECM11StandardEnrico LugliLab of Translational ImmunologyT cell intrinsic regulation of genome integrity in cancer immunology and immunotherapy
MECM12StandardMatteo Della PortaGenomics of Hematological Malignances LabA longitudinal single-cell multi-omic approach to define the mechanisms of disease progression in patients with TP53-mutated MDS
MECM13StandardRaffaella BonecchiChemokine biology labDissection of neutrophils heterogeneity in glioblastoma
MECM15Data ScienceMarta ScorsettiPietro MancosuClinical unit: Radiotherapy and RadiosurgeryPhoton-Counting CT in Personalized Radiotherapy: Imaging Protocol Optimization and Spectral Modeling
MECM16StandardMaria RescignoMucosal immunology and microbiota LabEvaluating the Impact of Proton Pump Inhibitors and mucosal protecting natural derived compound on Immune Checkpoint Blockade Efficacy
MECM17StandardMaria RescignoMucosal immunology and microbiota LabUnveiling the Impact of Intratumoral Microbiota on Soft Tissue Sarcoma Treatment: Challenges and Strategies to Enhance Chemotherapy Efficacy
MECM18StandardSimona LodatoDevelopmental neurobiology LabUnveiling the Neurobehavioral Implications of Inborn Error of Immunity Disorders: A Focus on WHIM Syndrome
MECM19StandardSimona LodatoDevelopmental neurobiology LabRole of CSF in Spontaneous Activity During Development: Cortical Research on Human 3D Models
MECM21StandardDi Pasquale Elisa
Condorelli Gianluigi
Cardiovascular Stem Cell Biology LabPrecision Human Organs-on-chip for Enhanced Neuro-muscular and Cardiac Studies (PHOENIX)
MECM22Data ScienceGabriele MicaliMicrobial Ecology LabMicrobial-Driven Bile Acid Modifications and Their Impact on Gut Ecology
MECM23Data ScienceGabriele MicaliMicrobial Ecology LabMicrobial-Driven Bile Acid Modifications and Their Impact on Gut Ecology
MECM25Data ScienceGabriele MicaliMicrobial Ecology LabMicrobial-Driven Bile Acid Modifications and Their Impact on Gut Ecology
MECM26StandardMaria RescignoMucosal immunologyAnalysis of drug effects on nasal tissue samples from healthy donors and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) patients
MECM27StandardGiulio StefaniniCardio CenterSGLT-2 inhibitors and coronary artery disease progression after an acute coronary syndrome in patients with diabetes mellitus
MECM28StandardRaffaella Bonecchi
Barbara Bottazzi
Chemokine biology labThe Role of Migration Stimulating Factor (MSF) in Neutrophil Infiltration in Pancreatic Cancer and Malignant Mesothelioma